Effects of eight InDel variants in FHIT on milk traits in Xinjiang brown cattle

In our previous genome-wide association study (GWAS), we identified the fragile histidine triad diadenosine triphosphatase (FHIT) gene in Xinjiang brown cattle (XJBC) as a candidate gene associated with cattle productive traits, with potential application in mark-assisted selection (MAS) in cattle breeding. 

FHIT is a prototype of a class of tumor suppressor genes that contain genomic loci mapped to common fragile loci. Here, 388 healthy and unrelated XJBC were selected to identify insertion/deletion (InDel) variants in the bovine FHIT and assess their effects on milk traits.

Etoposide (100 mM)

1043-100
EUR 153

S-100 Antibody

3958-100
EUR 316

rIgG FRET 100

RI1015-100 1 Kit
EUR 212

hInsulin FRET 100

IH1010-100 1 Kit
EUR 212

hInsulin TRF 100

IHTR1010-100 1 Kit
EUR 239

Biotin TRF 100

BTTR-1006-100 1 Kit
EUR 239

Rv0351 (GrpE)-100

AR02-P0003-100 100ug
EUR 266

Rv1009 (RpfB)-100

AR02-P0006-100 100ug
EUR 1133

Rv2450c (RpfE)-100

AR02-P0007-100 100ug
EUR 1133

Rv3875 (esxA)-100

AR02-P0008-100 100ug
EUR 1133

Rv2031c(HspX)-100

AR02-P0009-100 100ug
EUR 1133

Rv3131 (NfnB)-100

AR02-P0010-100 100ug
EUR 1133

PBS Tablets (100 ml)

2865-100
EUR 164

ATP Solution (100 mM)

2121-100
EUR 126

Mouse IgG FRET 100

MIG1012-100 1 Kit
EUR 212

Mouse IgM FRET 100

IM1009-100 1 Kit
EUR 212

CD1b(100-1A5) Antibody

BNC041044-100 100uL
EUR 199
Description: Primary antibody against CD1b(100-1A5), CF405S conjugate, Concentration: 0.1mg/mL

CD1b(100-1A5) Antibody

BNC431044-100 100uL
EUR 199
Description: Primary antibody against CD1b(100-1A5), CF543 conjugate, Concentration: 0.1mg/mL

CD1b(100-1A5) Antibody

BNCH1044-100 100uL
EUR 199
Description: Primary antibody against CD1b(100-1A5), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

CD1b(100-1A5) Antibody

BNC551044-100 100uL
EUR 199
Description: Primary antibody against CD1b(100-1A5), CF555 conjugate, Concentration: 0.1mg/mL

CD1b(100-1A5) Antibody

BNC941044-100 100uL
EUR 199
Description: Primary antibody against CD1b(100-1A5), CF594 conjugate, Concentration: 0.1mg/mL

CD1b(100-1A5) Antibody

BNC801044-100 100uL
EUR 199
Description: Primary antibody against CD1b(100-1A5), CF680 conjugate, Concentration: 0.1mg/mL

CD1b(100-1A5) Antibody

BNC401044-100 100uL
EUR 199
Description: Primary antibody against CD1b(100-1A5), CF640R conjugate, Concentration: 0.1mg/mL

CD1b(100-1A5) Antibody

BNC471044-100 100uL
EUR 199
Description: Primary antibody against CD1b(100-1A5), CF647 conjugate, Concentration: 0.1mg/mL

CD1b(100-1A5) Antibody

BNCAP1044-100 100uL
EUR 199
Description: Primary antibody against CD1b(100-1A5), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD1b(100-1A5) Antibody

BNCB1044-100 100uL
EUR 199
Description: Primary antibody against CD1b(100-1A5), Biotin conjugate, Concentration: 0.1mg/mL

CD1b(100-1A5) Antibody

BNC811044-100 100uL
EUR 199
Description: Primary antibody against CD1b(100-1A5), CF680R conjugate, Concentration: 0.1mg/mL

CD1b(100-1A5) Antibody

BNC701044-100 100uL
EUR 199
Description: Primary antibody against CD1b(100-1A5), CF770 conjugate, Concentration: 0.1mg/mL

CD1b(100-1A5) Antibody

BNC881044-100 100uL
EUR 199
Description: Primary antibody against CD1b(100-1A5), CF488A conjugate, Concentration: 0.1mg/mL

CD1b(100-1A5) Antibody

BNC611044-100 100uL
EUR 199
Description: Primary antibody against CD1b(100-1A5), CF660R conjugate, Concentration: 0.1mg/mL

CD1b(100-1A5) Antibody

BNC681044-100 100uL
EUR 199
Description: Primary antibody against CD1b(100-1A5), CF568 conjugate, Concentration: 0.1mg/mL

FUNNEL, 100 MM, PP

6120P-100 12/pk
EUR 47
Description: Reusable Plastics; Reusable Funnels

CD1b(100-1A5) Antibody

BNC051044-100 100uL
EUR 199
Description: Primary antibody against CD1b(100-1A5), CF405M conjugate, Concentration: 0.1mg/mL

CD1b(100-1A5) Antibody

BNUB1044-100 100uL
EUR 209
Description: Primary antibody against CD1b(100-1A5), Concentration: 0.2mg/mL

GFP Antibody, 100 uL

P601-100 - Ask for price

100 BlotBot Reagent Reservoirs

RRVR-100 100pack
EUR 177
Description: BlotBot reagent reservoirs will allow dispensing of unique reagents during processing. Pack of 100.

100 bp DNA Ladder (100 bp ~ 1,500 bp, with loading dye)

W0636-100 - Ask for price

Bridge-It cAMP-PDE 100

PD1007-100 1 Kit
EUR 239

Triton® X-100 Detergent

B2394-100
EUR 109

S-100?? Protein, Bovine Brain

P1275-100
EUR 403

ERLENMEYER FLASK, 100 ML, PP

4985P-100 6/pk
EUR 54
Description: Reusable Plastics; Reusable Erl Flasks

ERLENMEYER FLASK, 100 ML, PMP

4990P-100 6/pk
EUR 57
Description: Reusable Plastics; Reusable Erl Flasks

bcl-2(100/D5) Antibody

BNC040045-100 100uL
EUR 199
Description: Primary antibody against bcl-2(100/D5), CF405S conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

BNC430045-100 100uL
EUR 199
Description: Primary antibody against bcl-2(100/D5), CF543 conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

BNCH0045-100 100uL
EUR 199
Description: Primary antibody against bcl-2(100/D5), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

BNC610045-100 100uL
EUR 199
Description: Primary antibody against bcl-2(100/D5), CF660R conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

BNC800045-100 100uL
EUR 199
Description: Primary antibody against bcl-2(100/D5), CF680 conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

BNC470045-100 100uL
EUR 199
Description: Primary antibody against bcl-2(100/D5), CF647 conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

BNC550045-100 100uL
EUR 199
Description: Primary antibody against bcl-2(100/D5), CF555 conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

BNCB0045-100 100uL
EUR 199
Description: Primary antibody against bcl-2(100/D5), Biotin conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

BNC810045-100 100uL
EUR 199
Description: Primary antibody against bcl-2(100/D5), CF680R conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

BNC700045-100 100uL
EUR 199
Description: Primary antibody against bcl-2(100/D5), CF770 conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

BNC880045-100 100uL
EUR 199
Description: Primary antibody against bcl-2(100/D5), CF488A conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

BNC940045-100 100uL
EUR 199
Description: Primary antibody against bcl-2(100/D5), CF594 conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

BNC680045-100 100uL
EUR 199
Description: Primary antibody against bcl-2(100/D5), CF568 conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

BNCAP0045-100 100uL
EUR 199
Description: Primary antibody against bcl-2(100/D5), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

BNC050045-100 100uL
EUR 199
Description: Primary antibody against bcl-2(100/D5), CF405M conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

BNC400045-100 100uL
EUR 199
Description: Primary antibody against bcl-2(100/D5), CF640R conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

BNUB0045-100 100uL
EUR 209
Description: Primary antibody against bcl-2(100/D5), Concentration: 0.2mg/mL

Reflex Clips, 7mm , 100/Pk

LC1001-100 100/pk
EUR 147

Rv2769c (PE27 protein)-100

AR02-P0001-100 100ug
EUR 479

2.5x12 cellogel 250µ (100)

EHCA1200-ST01-100 ea
EUR 87

2.5x17 cellogel 200µ (100)

EHCA1200-ST12-100 ea
EUR 123

4x17 cellogel 250µ (100)

EHCA1200-ST21-100 ea
EUR 169

4x17 cellogel 200µ (100)

EHCA1200-ST22-100 ea
EUR 169

5.7x14 cellogel 250µ (100)

EHCA1200-ST36-100 ea
EUR 160

5.7x14 cellogel 200µ (100)

EHCA1200-ST37-100 ea
EUR 160

5.7x17 cellogel 250µ (100)

EHCA1200-ST77-100 ea
EUR 223

bcl-2(100/D5 + 124) Antibody

BNC041234-100 100uL
EUR 199
Description: Primary antibody against bcl-2(100/D5 + 124), CF405S conjugate, Concentration: 0.1mg/mL

Sodium Pyruvate Solution, 100 mM Solution

CCM1753-100 100 mL
EUR 60.84

bcl-2(100/D5 + 124) Antibody

BNC431234-100 100uL
EUR 199
Description: Primary antibody against bcl-2(100/D5 + 124), CF543 conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5 + 124) Antibody

BNCB1234-100 100uL
EUR 199
Description: Primary antibody against bcl-2(100/D5 + 124), Biotin conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5 + 124) Antibody

BNC551234-100 100uL
EUR 199
Description: Primary antibody against bcl-2(100/D5 + 124), CF555 conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5 + 124) Antibody

BNC941234-100 100uL
EUR 199
Description: Primary antibody against bcl-2(100/D5 + 124), CF594 conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5 + 124) Antibody

BNC401234-100 100uL
EUR 199
Description: Primary antibody against bcl-2(100/D5 + 124), CF640R conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5 + 124) Antibody

BNC471234-100 100uL
EUR 199
Description: Primary antibody against bcl-2(100/D5 + 124), CF647 conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5 + 124) Antibody

BNCAP1234-100 100uL
EUR 199
Description: Primary antibody against bcl-2(100/D5 + 124), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5 + 124) Antibody

BNC801234-100 100uL
EUR 199
Description: Primary antibody against bcl-2(100/D5 + 124), CF680 conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5 + 124) Antibody

BNC811234-100 100uL
EUR 199
Description: Primary antibody against bcl-2(100/D5 + 124), CF680R conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5 + 124) Antibody

BNC681234-100 100uL
EUR 199
Description: Primary antibody against bcl-2(100/D5 + 124), CF568 conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5 + 124) Antibody

BNC701234-100 100uL
EUR 199
Description: Primary antibody against bcl-2(100/D5 + 124), CF770 conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5 + 124) Antibody

BNC881234-100 100uL
EUR 199
Description: Primary antibody against bcl-2(100/D5 + 124), CF488A conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5 + 124) Antibody

BNC611234-100 100uL
EUR 199
Description: Primary antibody against bcl-2(100/D5 + 124), CF660R conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5 + 124) Antibody

BNUB1234-100 100uL
EUR 209
Description: Primary antibody against bcl-2(100/D5 + 124), Concentration: 0.2mg/mL

bcl-2(100/D5 + 124) Antibody

BNCH1234-100 100uL
EUR 199
Description: Primary antibody against bcl-2(100/D5 + 124), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5 + 124) Antibody

BNC051234-100 100uL
EUR 199
Description: Primary antibody against bcl-2(100/D5 + 124), CF405M conjugate, Concentration: 0.1mg/mL

Microscope Slide Boxes,100-Place, Blue

LC7002-100 100/CS
EUR 806

Microscope Slide Boxes,100-Place, Green

LC7003-100 100/CS
EUR 806

Microscope Slide Boxes,100-Place, Red

LC7004-100 100/CS
EUR 806

Microscope Slide Boxes,100-Place, Yellow

LC7005-100 100/CS
EUR 806

Microscope Slide Boxes,100-Place, White

LC7006-100 100/CS
EUR 806

MTBK 20620 (PE protein)-100

AR02-P0005-100 100ug
EUR 1414

Sodium Chloride tablets 100 ml

09-9103-100 100 ml
EUR 73

2.5x14 cellogel 190µ hr (100)

EHCA1200-ST08-100 ea
EUR 105

2.5x17 cellogel 190µ hr (100)

EHCA1200-ST13-100 ea
EUR 123

4x17 cellogel 190µ hr (100)

EHCA1200-ST23-100 ea
EUR 169

5.7x14 cellogel 190µ hr (100)

EHCA1200-ST38-100 ea
EUR 160

Bcl-2 Antibody (Clone Bcl-2/100)

3195-100
EUR 359

QuantiChrom? LDH Cytotoxicity Assay Kit (C2LD-100)

C2LD-100 100
EUR 127.43
Description: Quantitative determination of cytotoxicity based on cellular lactate dehydrogenase release into cell culture medium by colorimetric (565nm) method. Procedure: 30 min. Kit size: 100 tests. Detection limit: 2 U/L. Shelf life: 6 months. Shipping: ambient tem

Universal DNA Marker (100 bp ~ 10,000 bp)

W2583-100 - Ask for price

DiagNano Fluorophore Labeled Gold Nanoparticles, 100 nm

GFL-100 1 mL
EUR 1053

Meat sample spatulas (individually wrapped) 100/pk

MSSW-100 1 pk
EUR 61

Deacetylase Inhibitor Cocktail (100× in 70% DMSO)

K1017-100 100x1 ml
EUR 1163

Rv0350 (Heat Shock Protein 70)-100

AR02-P0002-100 100ug
EUR 277

Rv2299c (Heat Shock Protein 90)-100

AR02-P0004-100 100ug
EUR 351

2.5x13 cellogel 200µ practiga punched (100)

EHCA1200-ST11-100 ea
EUR 123

5.7x14 cellogel 200µ pratiga punched (100)

EHCA1200-ST43-100 ea
EUR 169

5.7x14.5 cellogel 200µ beckman punched (100)

EHCA1200-ST53-100 ea
EUR 169

Triton® X-100, MegaPure? Detergent, 10% Solution

2124-100
EUR 191

Solution Basin,100 ml Sterile Polystyrene,10/pk

LC2005-100 100/CS
EUR 246

DiagNano Gold Nanoparticle Passive Conjugation Kit, 100 nm

GPK-100 1 kit
EUR 715

CryoSolutions 100%

AK8899-0005 5mL Ask for price

CryoSolutions 100%

AK8899-0010 10mL Ask for price

CryoSolutions 100%

AK8899-0030 30mL Ask for price

CryoSolutions 100%

AK8899-0100 100mL Ask for price

LB-100

B2031-25
EUR 588

LB-100

B2031-5
EUR 185

pEarleyGate 100

PVT12182 2 ug
EUR 703

S-100

MO47059 100 ul
EUR 349

AIM-100

HY-15290 10mM/1mL
EUR 201

SW-100

HY-115475 10mM/1mL
EUR 366

HA-100

HY-100984 10mM/1mL
EUR 141

TritonX-100

T9500-010 100ml
EUR 77

ARP 100

A4432-10 10 mg
EUR 261
Description: ARP 100 is a selective inhibitor of matrix metalloproteinases 2 (MMP-2) with IC50 value of 12 nM [1].

ARP 100

A4432-5 5 mg
EUR 166
Description: ARP 100 is a selective inhibitor of matrix metalloproteinases 2 (MMP-2) with IC50 value of 12 nM [1].

AIM-100

A3148-10 10 mg
EUR 267
Description: AIM-100 is a small inhibitor of Ack1 tyrosine kinase with IC50 value of 24 nM [1]. AIM-100 mimicked ATP and inhibited the activity of Ack1 significantly and specifically.

AIM-100

A3148-5 5 mg
EUR 231
Description: AIM-100 is a small inhibitor of Ack1 tyrosine kinase with IC50 value of 24 nM [1]. AIM-100 mimicked ATP and inhibited the activity of Ack1 significantly and specifically.

AIM-100

A3148-50 50 mg
EUR 991
Description: AIM-100 is a small inhibitor of Ack1 tyrosine kinase with IC50 value of 24 nM [1]. AIM-100 mimicked ATP and inhibited the activity of Ack1 significantly and specifically.

LB-100

B4846-25 25 mg
EUR 438

LB-100

B4846-5 5 mg
EUR 171

PTPRF(His tagged) / LAR(His tagged)-100

AR09-P0002-100 100ug
EUR 718

Total RNA Plus Mini Kit (100 prep)

FATRK-P-100 100 preps
EUR 242

Triton® X-100 Solution (10% in H?O)

2104-100
EUR 137

Cell Strainer, 100 µm, Sterile, Individually Wrapped, Nylon Mesh

LC3070-100 100/CS
EUR 219

Single channel mini-pipette (130 mm) 100 ul, autoclavable

SCMP-100 1
EUR 92

miRZip-100 anti-miR-100 microRNA construct

MZIP100-PA-1 Bacterial Streak
EUR 684

slingshot homolog 1 (SSH1)(MBP-his tagged)-100

AR09-P0023-100 100ug
EUR 8007

slingshot homolog 3 (SSH3)(MBP-his tagged)-100

AR09-P0024-100 100ug
EUR 1182

Phosphate Buffered Saline (PBS) pH 7.4, 100 ml

09-2051-100 100 ml
EUR 75

Carbonate-bicarbonate Coating buffer pH 9.6, 100 ml

09-8922-100 100 ml
EUR 108

RESERVOIR, POLYPROPYLENE, 100 ML, V-BOTTOM, NONSTERILE, BULK

RES-V-100 25/pk
EUR 67
Description: Reservoirs; Reservoirs - Axygen

Mouse pre-microRNA Expression Construct mir-100

MMIR-100-PA-1 Bacterial Streak
EUR 684

Rabbit Soluble protein-100,S-100 ELISA Kit

CN-00730R1 96T
EUR 439

Rabbit Soluble protein-100,S-100 ELISA Kit

CN-00730R2 48T
EUR 290

Rat Soluble protein-100,S-100 ELISA Kit

CN-01451R1 96T
EUR 434

Rat Soluble protein-100,S-100 ELISA Kit

CN-01451R2 48T
EUR 284

Mouse Soluble protein-100,S-100 ELISA Kit

CN-02321M1 96T
EUR 447

Mouse Soluble protein-100,S-100 ELISA Kit

CN-02321M2 48T
EUR 296

Human Soluble protein-100,S-100 ELISA Kit

CN-03332H1 96T
EUR 449

Human Soluble protein-100,S-100 ELISA Kit

CN-03332H2 48T
EUR 299

Human Soluble protein- 100, S- 100 ELISA Kit

SELI-66017h 96 Tests
EUR 657

Mouse Soluble protein- 100, S- 100 ELISA Kit

SELI-66073m 96 Tests
EUR 657

Rat Soluble protein- 100, S- 100 ELISA Kit

SELI-66096r 96 Tests
EUR 657

Rabbit Soluble protein- 100, S- 100 ELISA Kit

SELI-66124Rb 96 Tests
EUR 657

Human Soluble protein-100, S-100 ELISA Kit

CSB-E08067h-24T 1 plate of 24 wells
EUR 165
Description: Quantitativesandwich ELISA kit for measuring Human Soluble protein-100, S-100 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Soluble protein-100, S-100 ELISA Kit

1-CSB-E08067h
  • EUR 703.00
  • EUR 4843.00
  • EUR 2570.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Soluble protein-100, S-100 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Eight of the thirteen InDel loci were found to be polymorphic in FHIT. The polymorphism information content of the eight loci ranged from 0.061 to 0.375. The correlation analysis showed that all the new InDel variants were significantly related to six different milk traits (p < 0.05).

The following variants presented a significant relationship with productive traits: P2-23bp with the 305 milk yield (p = 0.005) in the sixth parity; P3-24bp with the milk fat yield (p = 0.009) in the third parity; P5-21bp with the somatic cell score (p = 0.001) in the first parity and with the milk protein percentage (p = 0.002) in the sixth parity; and P7-26bp with the somatic cell score (p = 0.003) in the sixth parity. These findings will help evaluate InDel genotypes, within and between cattle breeds and identify potential target loci to accelerate progress in MAS in cattle breeding.